Articles: respiratory-distress-syndrome.
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Laryngo- rhino- otologie · Jan 1994
[Surgical treatment of pediatric laryngeal stenosis in the area of the ring cartilage].
In the past 15 years, infants and children with laryngeal stenosis have also been successfully treated with laryngotracheoplasty. From 1991 to 1993 we performed a surgical treatment in 20 pediatric patients with subglottic stenosis. ⋯ In 14 patients with a tracheostoma we used a modification of Réthi's division of the posterior lamina of the cricoid by the placement of a autogenous costal cartilage graft. A 6-week-period of stenting is required for sufficient healing and stability of the reconstructed airway.
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Bronchopleural fistula (BPF) continues to present a treatment problem in mechanically ventilated patients. We report a patient with a traumatic BPF, pneumonia, and adult respiratory distress syndrome (ARDS) who was successfully ventilated with pressure-controlled ventilation (PCV). This mode, by allowing the use of lower inspiratory airway pressures, may promote closure of the fistula.
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Elevated airway pressures during mechanical ventilation are associated with hemodynamic compromise and pulmonary barotrauma. We studied the cardiopulmonary effects of a pressure-limited mode of ventilation (airway pressure release ventilation) in patients with the adult respiratory distress syndrome. ⋯ Our results suggest that while airway pressure release ventilation can provide similar oxygenation and ventilation at lower peak and end-expiratory pressures, this offers no hemodynamic advantages.
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Critical care medicine · Dec 1993
A novel leukotriene B4-receptor antagonist in endotoxin shock: a prospective, controlled trial in a porcine model.
To evaluate the hypothesis that treatment with LY255283, a novel leukotriene B4-receptor antagonist, is beneficial in an animal model of the adult respiratory distress syndrome induced by endotoxin. ⋯ These data suggest that leukotriene B4 may be an important mediator of acute lung injury in this porcine model of septic shock and acute lung injury. Further studies to assess the specificity of LY255283 as a leukotriene B4 antagonist are necessary in order to exclude the possibility that the beneficial effects of this compound are due to pharmacologic actions other than the blockade of LTB4 receptors.