Articles: critical-illness.
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Intensive care medicine · Mar 1995
Comparative Study Retracted PublicationAlterations in circulating vasoactive substances in the critically ill--a comparison between survivors and non-survivors.
Regulation of circulatory homeostasis is based on several factors including various circulating vasoactive substances. Whether these regulators differ between survivors and non-survivors was investigated in critically ill patients. ⋯ Systemic and regional regulators of the circulation were markedly changed by critical illness. In survivors, these regulators almost normalized within the study period of 5 days, whereas in non-survivors these alterations were even aggravated. It can only be speculated whether these regulator systems were influenced by activation of various mediator systems or whether they themselves influenced the negative outcome in the non-survivors.
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Retracted Publication
Do plasma levels of circulating soluble adhesion molecules differ between surviving and nonsurviving critically ill patients?
Adhesion molecules appear to play a central role in tissue damage secondary to inflammatory response. Besides various neutrophil- and endothelial-bound adhesion molecules, soluble forms of endothelial-derived adhesion molecules have been detected in the circulating blood in recent years. They seem to be good markers of endothelial damage, but their importance in the critically ill has not been definitely elucidated yet. ⋯ None of the other hemodynamic or laboratory variables could be correlated with the time course of adhesion molecules, except for PaO2/Pao2 ratio, which was negatively correlated with plasma levels of soluble adhesion molecules in the nonsurvivors (analysis of covariance). It is concluded that plasma levels of soluble adhesion molecules were markedly higher in nonsurviving than in surviving critically ill patients. They may possibly serve as markers of the extent of inflammatory response, of the endothelial damage in patients at risk of multiple-organ failure or both.(ABSTRACT TRUNCATED AT 400 WORDS)
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Critical care medicine · Dec 1994
Comparative Study Retracted PublicationIs continuous cardiac output measurement using thermodilution reliable in the critically ill patient?
Evaluation of continuous cardiac output monitoring based on the thermodilution technique in the critically ill. ⋯ Continuous monitoring of cardiac output using a modified pulmonary artery catheter with a heated filament has proven to be accurate and precise in the critically ill patient when compared with the "standard" intermittent bolus thermodilution technique. The continuous monitoring technique enhances our armamentarium for more intensive monitoring of these patients under a variety of circumstances.