Articles: critical-illness.
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This article reviews the current body of knowledge regarding lactic acidosis in critically ill patients. The classification of disordered lactate metabolism and its pathogenesis are examined. The utility of lactate as a metabolic monitor of shock is examined and current therapeutic strategies in the treatment of patients suffering from lactic acidosis are extensively reviewed. The paper is designed to integrate basic concepts with a current approach to lactate in critical illness that the clinician can use at the bedside. ⋯ The severity of lactic acidosis in critically ill patients correlates with overall oxygen debt and survival. Lactate determinations may be useful as an ongoing monitor of perfusion as resuscitation proceeds. Therapy of critically ill patients with lactic acidosis is designed to maximize oxygen delivery in order to reduce tissue hypoxia by increasing cardiac index, while maintaining hemoglobin concentration. Buffering agents have not been shown to materially affect outcome from lactic acidosis caused by shock. The benefits of other specific therapies designed to reduce the severity of lactic acidosis remain unproven.
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This review focuses on the neurologic issues concerning the treatment of hypo- or hyperglycemia in the critically ill patient. ⋯ Because both hypo- and hyperglycemia may produce neurologic changes, aggressive management of abnormal glucose values is warranted.
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AACN Clin Issues Crit Care Nurs · Nov 1991
ReviewNeuromuscular blocking agents in the critically ill patient: neither sedating nor pain relieving.
Although neuromuscular blocking agents (NMBAs), such as pancuronium bromide and succinylcholine, are widely used in the management of critically ill patients, many misconceptions regarding the agents' clinical effects and indications persist. This article will discuss these misconceptions and review the indications for the use of NMBAs in the critically ill patient, how these potent agents work, and strategies to effectively manage critically ill patients who are receiving NMBAs as a part of their treatment regimen.
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Review Comparative Study
Transesophageal two-dimensional echocardiography in the critically ill--is the Swan-Ganz catheter redundant?
Swan-Ganz catheterization can facilitate intra-operative management of critically ill patients. The derived data lacks specificity, however, and, as such, is frequently misleading. This disadvantage, combined with recent advances in echocardiography imaging techniques, has resulted in increasing application of transesophageal (TE) two-dimensional echocardiography (2D-echo) to supplement and, in instances, to supplant conventional cardiac monitoring. ⋯ In contrast, corresponding estimates of LV ejection fraction correlate closely with overall performance, at least in cases without asynergy. Finally, the capacity of TE 2D-echo to detect LV regional wall-motion abnormalities can be particularly useful. Such abnormalities commonly represent early manifestations of ischemia and can, in addition, be predictive of subsequent outcome.