Articles: critical-illness.
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Intensive care medicine · Sep 2013
Letter Randomized Controlled TrialArginine administration to critically ill patients with a low nitric oxide fraction in the airways: a pilot study.
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Critical care medicine · Aug 2013
Randomized Controlled Trial Multicenter StudyEarly goal-directed sedation versus standard sedation in mechanically ventilated critically ill patients: a pilot study*.
To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. ⋯ Delivery of early goal-directed sedation was feasible, appeared safe, achieved early light sedation, minimized benzodiazepines and propofol, and decreased the need for physical restraints. The findings of this pilot study justify further investigation of early goal-directed sedation.
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Randomized Controlled Trial
Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition.
N-3 fatty acids (FA) may have benefits in ICU patients. The aims were to identify whether FA status is altered in critical illness and to evaluate the effect of supplemental intravenous n-3 FA on plasma FA status and clinical outcome in ICU patients receiving enteral nutrition. ⋯ Critically ill patients may have altered plasma FA profiles. A higher total n-3 FA and docosahexaenoic acid content in plasma PC is associated with survival and improved gas exchange.
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Randomized Controlled Trial
Feasibility of fully automated closed-loop glucose control utilizing continuous subcutaneous glucose measurements in critical illness: a randomised controlled trial.
Closed-loop (CL) systems modulate insulin delivery according to glucose levels without nurse input. In a prospective randomized controlled trial, we evaluated the feasibility of an automated closed-loop approach based on subcutaneous glucose measurements in comparison with a local sliding-scale insulin-therapy protocol. ⋯ Fully automated closed-loop control based on subcutaneous glucose measurements is feasible and may provide efficacious and hypoglycemia-free glucose control in critically ill adults.
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Randomized Controlled Trial
Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up.
The purpose of this trial was to investigate the effectiveness of an exercise rehabilitation program commencing during ICU admission and continuing into the outpatient setting compared with usual care on physical function and health-related quality of life in ICU survivors. ⋯ Further research examining the trajectory of improvement with rehabilitation is warranted in this population.