Articles: anesthetics.
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Eur J Anaesthesiol Suppl · Jan 1987
Fixed-rate alfentanil infusions for surgery of variable duration.
The continuous infusion of alfentanil with a modified Fresenius-injectomat infusion pump was studied in 27 patients undergoing orthopaedic operations of variable length. Patients were premedicated with diazepam 10 mg orally. Anaesthesia was induced with thiopentone, vecuronium and an anfentanil loading dose delivered by the infusion pump at a rate of 10 micrograms kg-1 min-1 for 10 min. ⋯ Recovery was uneventful in all but one patient, who had ventilatory depression that responded to naloxone. All patients were satisfied with their anaesthesia and recovery. The use of a 10-min, 10 micrograms kg-1 min-1 loading infusion, then a maintenance infusion of 1 microgram kg-1 min-1 delivered by a modified Fresenius-injectomat infusion pump may be the first step in simplifying the continuous infusion of alfentanil.
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Acta Anaesthesiol Scand · Jan 1987
Randomized Controlled Trial Comparative Study Clinical TrialPropofol vs thiopentone as anaesthetic agents for short operative procedures.
In a randomized open study, 120 healthy female patients were included. For short gynaecological procedures they were anaesthetized with either propofol 2.5 mg X kg-1 (n = 60) or thiopentone 5 mg X kg-1 (n = 60) in combination with nitrous oxide/oxygen (67%/33%). Supplementary doses of propofol (10-20 mg) or thiopentone (25-50 mg) were given when necessary during the procedure. ⋯ Otherwise, the side-effects were similar in both groups. We conclude that propofol is similar to thiopentone in its anaesthetic qualities during induction and maintenance of short anaesthetic procedures. Propofol was associated with a more rapid emergence from anaesthesia than thiopentone.
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Ann Fr Anesth Reanim · Jan 1987
Randomized Controlled Trial Comparative Study Clinical Trial[Comparative trial of propofol and ketamine in anesthesia for the baths of severely burnt patients].
Ketamine was the normal anaesthetic drug for carrying out the baths of severely burnt patients. It was compared with propofol in a study of 50 patients (greater than 50 UBS) randomly assigned to two groups: 2.5 mg . kg-1 propofol and 2 mg . kg-1 ketamine. The speed of induction was the same for both groups, surgery beginning within the same time intervals. ⋯ Respiratory rate increased, because of the lack of analgesia. Recovery was very quick, complete and with no bothersome adverse effects in the propofol group. These hypercatabolic patients could therefore be fed early postoperatively; also, there was no deleterious psychological interference in these deeply disturbed patients.
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Topically and intravenously administered local anaesthetic agents are widely used to inhibit cough, but little quantitative, pharmacological data seems to be available. Various aspects of local anaesthetic agents as inhibitors of cough and other airway reflexes are discussed. Nebulized lidocaine dose-dependently inhibited both mechanically (trachea, carina) and ammonia vapour-induced cough. ⋯ This observation is compatible with the view that the cough receptors are located close to the airway lumen and those mediating the Hering-Breuer reflex within the smooth muscle. Airway anaesthesia is commonly used to block the cough reflex during endoscopic procedures. Nebulized lidocaine has been reported also to suppress severe chronic cough but further studies on airway anaesthesia and cough in acute and chronic lung disease are warranted.
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Adv Tech Stand Neurosurg · Jan 1987
Review Comparative StudyNeuro-anaesthesia: the present position.
Over the years the basic principles underlying the practice of neuroanaesthesia have not changed, but introduction of new anaesthetic agents and associated techniques have improved the ability of the neuroanaesthetist to "fine tune" the patients physiological state. This has improved the capacity of the neuroanaesthetist to mitigate the inevitable fluctuations which occur and prevent their ill effects. ⋯ It takes years for the correct plan of usage of new drugs to be formulated for the clinical situation, and their relationships established to new techniques of patient monitoring. Like neurosurgery itself neuroanaesthesia shows no signs of approaching a final definitive state in the forseeable future.