Articles: anesthetics.
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ICI 35868 was used to induce anesthesia in 39 ASA I patients (9 male and 30 female, aged 17-64 years), scheduled to undergo minor surgical procedures. The first 6 patients were given 1.0 mg/kg, the next 22 1.5 mg/kg and the final 11 2.0 mg/kg ICI 35868 I. V. over 30 seconds, without premedication. ⋯ Other side effects were minor and of low incidence. Three minutes after induction of anesthesia, when assessments were complete, 23 patients were given a further dose of a conventional induction agent, as they were beginning to awaken, and anesthesia was maintained in all patients by inhalational techniques. There were no untoward events during maintenance of or on recover from anesthesia.
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Biography Historical Article
Crawford W. Long Museum reopens in Jefferson, Georgia.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of a chloroprocaine--bupivacaine mixture with chloroprocaine and bupivacaine used individually for obstetric epidural analgesia.
Continuous lumbar epidural anesthesia was instituted in 49 healthy parturients who were randomly assigned to three treatment groups: 14 patients received chloroprocaine, 3 per cent; 19 received bupivacaine, 0.5 per cent, and 16 received a mixture containing chloroprocaine, 1.5 per cent, and bupivacaine, 0.375 per cent. Observations relating to the characteristics of the anesthetic block and to maternal and fetal well-being were made by a trained nurse observer. ⋯ No clinical superiority could be demonstrate for the mixture as compared with bupivacaine or chloroprocaine used individually. There was no sign of material or fetal toxicity with any of the three treatment regimens.