Articles: nausea.
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Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
Domperidone in the prevention of post-operative nausea and vomiting.
In a series of open pilot studies, intravenous domperidone was given to three groups of post-operative patients, at doses ranging from 10 mg to 60 mg. As a result of these studies, it was decided that a regime of 20 mg initially, followed by maintenance doses of 10 mg at 6 hourly intervals was highly effective in preventing post-operative nausea and vomiting. ⋯ The results showed that only three out of 53 patients (5.7%) on active treatment were having nausea and vomiting compared with 16 of 53 patients (30.2%) on placebo. It is concluded that this regime is effective in preventing post-operative nausea and vomiting.
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Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
Postoperative nausea and vomiting treated with domperidone (r 33812) an open and a double-blind study.
The effect of domperidone on postoperative nausea and vomiting was evaluated in two consecutive studies. Fifty-eight patients with postoperative nausea and vomiting were included in an open pilot study and 38 other patients in a double-blind trial. ⋯ In the double-blind trial, vomiting recurred significantly later in domperidone than in placebo-treated patients. Side-effects were not seen nor reported in either study.
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Randomized Controlled Trial Clinical Trial
A trial of valoid (cyclizine) tablets in the control of the nausea and vomiting associated with radiation therapy.
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Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
The antiemetic effect of dixyrazine in postoperative patients-- a double-blind study.
A double-blind controlled study based on 197 women undergoing legal abortion (part I) or gynaecological surgery (part II) was employed to estimate the antiemetic effect of dixyrazine. Dixyrazine or part I) or intramuscularly at the end of anaesthesia (part II) and repeated when necessary. ⋯ Overall, a marked antiemetic response in the dixyrazine groups was observed when compared with the placebo treated groups in both part I and II (p less than 0.001). Dixyrazine proved to be superior to placebo especially in patients who were not prone to nausea or who received no major postoperative analgesics (p less than 0.001).
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Randomized Controlled Trial Comparative Study Clinical Trial
Metoclopramide and perphenazine in the prevention of postoperative nausea and vomiting.