Articles: nausea.
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Postoperative nausea and vomiting (PONV) is still a problem and is very discomforting for the patients. As surgery done on out-patient basis becomes more frequent, PONV will represent an important factor in the length of recovery room stay, and is in this way an economic problem. Based on the literature from 1985-1995 factors associated with increased risk, prevention and treatment of PONV are discussed in view of the physiological mechanisms. ⋯ It demands an individual evaluation with a careful preoperative visit including planning of both preanaesthetic and anaesthetic agents. Furthermore, a proper anaesthetic treatment of the per- and postoperative course is of high importance. Patients at high risk of PONV should be identified and given prophylactic antiemetics.
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In the past few years important progress in the prevention of chemotherapy-induced nausea and vomiting has been made mainly thanks to the introduction of the 5-HT3 receptor antagonists in clinical practice (ondansetron, granisetron, tropisetron). In the prevention of acute emesis induced by cisplatin, an intravenous combination of a 5-HT3 receptor antagonist plus single dose dexamethasone (20 mg) should be considered the treatment of choice. This is also the case in the prevention of acute emesis induced by moderately emetogenic chemotherapy (intravenous cyclophosphamide, doxorubicin, epirubicin, carboplatin, used alone or in combination), but high and repeated doses of dexamethasone should be used (8 mg intravenously plus 4 mg orally every 6 hours for four doses starting contemporarily to chemotherapy administration). ⋯ Ondansetron plus dexamethasone is a valid alternative regimen that should be preferred in patients who not tolerate metoclopramide and in patients who suffer from acute vomiting. In the prevention of delayed emesis induced by moderately emetogenic chemotherapy oral dexamethasone or oral ondansetron showed a good antiemetic efficacy, but the results from a recently published study seem suggest the necessity to treat only patients who present acute vomiting or moderate-severe nausea. In fact, patients obtaining complete protection from vomiting and nausea (or at most mild acute nausea) have a very low incidence of delayed emesis.
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Oncology nursing forum · Oct 1996
ReviewManaging the multiple causes of nausea and vomiting in the patient with cancer.
To review the multiple causes of nausea and vomiting in the patient with cancer. Pharmacologic and nonpharmacologic management strategies are provided to deal with each type, and selected clinical nursing research is discussed. ⋯ Healthcare providers must thoroughly assess and reassess the patient's disease status and current treatment interventions to effectively manage nausea and vomiting. Nurses can participate in this assessment and provide the appropriate drug therapies as well as continue to develop non-pharmacologic intervention methods that the patient can implement independently.
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There is a vast amount of research available relating to postoperative nausea and vomiting (PONV). This research has been analyzed and summarized in a series of two articles which draw out the main factors influencing the incidence and affecting the treatment of the condition. This, the first article, will describe the physiological processes that result in PONV. ⋯ These factors include personal, preoperative, intraoperative and postoperative variables which affect differing neurotransmitter centres in the chemoreceptor trigger zone (CTZ) which is situated in the brainstem. These variables will then be related to the appropriate neurotransmitter centre allowing a greater understanding of the most likely physiological pathways involved in specific cases of PONV. The second article will explore the management and treatment of PONV.
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Postoperative nausea and vomiting is an all too common side effect of surgery and anesthesia. The usual occurrence of vomiting within the first 24 hours following surgery involves one quarter to one third of all patients. ⋯ Patient dissatisfaction, adverse physiological sequelae, delays in discharge from the ambulatory facility, unanticipated hospital admission, and added cost are problems associated with postoperative vomiting. This article will review the multiple factors contributing to postoperative nausea and vomiting and discuss contemporary strategies for the management of these factors.