Articles: brain-injuries.
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Journal of neurosurgery · Mar 2001
Exacerbation of traumatically induced axonal injury by rapid posthypothermic rewarming and attenuation of axonal change by cyclosporin A.
Although considerable attention has been focused on the use of posttraumatic hypothermia, little consideration has been given to the issue of posthypothermic rewarming and its potentially damaging consequences. In this communication, the authors examine the issue of rapid posthypothermic rewarming compared with gradual rewarming while exploring the potential utility of cyclosporin A (CsA) administration for attenuating any rapid rewarming-induced axonal change. ⋯ The results of this study show that rapid rewarming exacerbates traumatically induced axonal injury, which can be significantly attenuated by administering CsA.
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Neurol Neurochir Pol · Mar 2001
[Dynamics of cerebral circulation on the basis of transcranial Doppler ultrasonography evaluation in patients with moderate and minor head injury].
Patients with moderate and minor head injury were evaluated with transcranial Doppler ultrasonography (TCD) and the relationship was studied between traumatic vasospasm (TVSP) and hyperaemia and the patients' age, clinical state, head CT examination and long-term results of treatment. The group examined consisted of 45 patients. ⋯ TVSP was observed in about 20% while hyperaemia occurred in 25% of the cases. Traumatic vasospasm in transcranial Doppler ultrasonography was found to occur most often in the group of patients with subdural or intracerebral haematomas.
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Journal of neurosurgery · Mar 2001
Diminution of metabolism/blood flow uncoupling following traumatic brain injury in rats in response to high-dose human albumin treatment.
The authors have recently demonstrated that high-dose human albumin is markedly neuroprotective in experimental traumatic brain injury (TBI) and cerebral ischemia. The pathophysiology of TBI involves acute uncoupling of cerebral glucose utilization and blood flow. The intent of this study was to establish whether the use of human albumin therapy in a model of acute TBI would influence this phenomenon. ⋯ These results demonstrate that human albumin therapy benefits the posttraumatic brain by diminishing the pronounced metabolism > blood flow dissociation that would otherwise occur within the 1st hour after injury. Viewed together with our previous evidence of histological neuroprotection, these findings indicate that human albumin therapy may represent a desirable treatment modality for acute TBI.
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Archiv für Kriminologie · Mar 2001
Case Reports[Suicide with a walking cane gun: weapon, injury picture and psychopathology].
In Germany firearms camouflaged as items of daily use are forbidden. While reports on ball-point pen-guns have repeatedly been published in literature, the use of a walking-stick gun is a rarity. ⋯ Under forensic and criminological aspects the significance of a walking-stick gun is comparable to that of ball-point pen-guns. Both weapons can be carried and used inconspicuously, but from a walking-stick gun also ammunition of larger calibres with a higher potential of injury can be fired.
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Editorial Comment
Hypothermia for traumatic brain injury--a good idea proved ineffective.