Articles: brain-injuries.
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Acta Neurochir. Suppl. · Jan 2000
Time profile of neuron specific enolase serum levels after experimental brain injury in rat.
The aim of this study was to investigate the time course of NSE serum levels after traumatic brain injury in rats. 65 male Wistar rats were subjected to severe cortical impact injury (100 PSI, 2 mm deformation). Blood samples were drawn directly after trauma, after 1 h, 6 h, 12 h, 24 h, and 48 h in the trauma group as well as in sham operated animals directly after craniotomy, after 6 h and after 48 h. NSE serum levels were estimated with a commercially available enzyme immuno assay (LIA-mat Sangtec). ⋯ We demonstrated a time dependent release of NSE into the serum after trauma. The highest NSE serum values were detected six hours after trauma (31.5 micrograms/l, mean, n = 10). NSE serum level seems to reflect neuronal damage after cortical contusion in the rat in a time dependent manner.
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Hua Xi Yi Ke Da Xue Xue Bao · Dec 1999
[The establishment of a modified lateral fluid percussion model of brain injury in rat and the pertinent pathologic changes].
For the purpose of studying the molecular mechanism of the traumatic brain injury, we have established a reproducible graded lateral fluid percussion model of experimental brain injury in the rat with a modified fluid percussion device. The device consists of a stainless steel cylindrical reservoir instead of the plexiglass reservoir, a steel reservoir filled with compressed gas instead of the pendulum for making more accurate percussion pressure, an apparatus for releasing the pressure immediately after the percussion, and a computer for recording and storing the percussion data. ⋯ The severity of pathologic changes increased with the magnitude of percussion. The results indicate that the new device could inflict reproducible graded lateral fluid percussion brain injury on rats and the model can be used for the studies of neuropathologic and molecular mechanism of brain injury.
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J Head Trauma Rehabil · Dec 1999
Neuropsychological significance of anosmia following traumatic brain injury.
To investigate the incidence of anosmia following traumatic brain injury (TBI) using a standardized instrument and to test hypotheses that post-TBI anosmics perform significantly more poorly than do post-TBI normosmics on measures of executive skills and functional outcome. ⋯ Anosmia is a common sequela of TBI, although only a minority of patients are aware of this deficit. Further, anosmics demonstrated greater impairment in a variety of frontal-lobe mediated executive functions, as well as greater functional disability.