Articles: brain-injuries.
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Gunshot disturbances of different severeness were induced in rabbit brain by means of specifically worked out experimental model. Cerebral cortex was studied using light and electron microscopy in severe gunshot craniocerebral trauma (SGCT), accompanied with cranial bones and cerebral disorders, plentiful external and internal hemorrhages and death of the animals 1-5 minutes after the shot. Peculiarities of responsiveness to trauma were demonstrated in microcirculatory bed elements, neurons and glial cells. SGCT causes rapid appearance of destructive changes in cerebral cortex with degenerative processes not following hemomicrocirculatory bed disturbances, but developing simultaneously with them.
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Journal of neurotrauma · Dec 1995
Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume.
Controlled cortical impact (CCI) is a contemporary model of experimental cerebral contusion. We examined the cerebrovascular and neuropathologic effects of a severe CCI in rats. The utility of magnetic resonance imaging (MRI) for the assessment of contusion volume after severe CCI was also established. ⋯ Estimates of contusion volume by MRI and histology were closely correlated (r = 0.941, p < 0.017). Severe CCI in rats is accompanied by contusion, reproducible edema, and marked hypoperfusion, involving over 14% of the injured hemisphere, and can be produced with minimal mortality. T2-weighted MRI successfully and noninvasively identifies contusion volume in this model.