Post-op nausea & vomiting incidence is related to duration of nitrous oxide exposure, but is clinically insignificant at under 1 hour exposure.
Drug treatment for pulmonary hypertension improved 6-minute walk distance and reduced hospitalisation. Combination is more effective than monotherapy.
12-16h of post-op supplemental O2 (80%) does not reduce wound infection or complication in the morbidly obese undergoing gastric bypass.
Addition of paracetamol or NSAIDs significantly reduces post-operative opioid consumption in children, although not demonstrably opioid side effects.
Perineural dexamethasone may improve post-op analgesia for sciatic blocks but not for ankle blocks when compared with systemic dexamethasone.
Intraoperative nitrous oxide use does not improve post-operative analgesia or reduce opioid consumption.
Greater depth of general anaesthesia as measured by Bispectral Index Score (target BIS 30-40) does not reduce post-operative pain.
Adjuvant perineural dexamethasone (4-10 mg) prolongs brachial plexus sensory and motor blockade by between 65% and 100% longer.
Peri-operative nicotine very slightly reduces opioid consumption in non-smokers but not pain scores — and increases the incidence of post-op nausea.
Neither speed of onset or duration of Labat sciatic block is influenced by volume or LA concentration when the total dose of mepivacaine is constant.
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