Women who received epidural analgesia during labour had a lower risk of post-natal depression at 6 weeks (OR 0.30), similar to the lowered risk in those who attended childbirth classes (OR 0.30).
Although improving, 'harms reporting' in analgesic clinical trials is generally poor. On average the 101 studied analgesic trials met only 60% of harms reporting recommendations.
Sedation with TCI remifentanil targeting effect site concentration of 3 ng/mL resulted in detectable aspiration in almost 50% of the study participants after 1 hour.