Article Notes
- Paravertebral – OR 3.62 [95% CI, 1.33–7.86]
- Upper limb — OR 1.75 [95% CI, 0.93–2.99]
- Lower limb — OR 0.24 [95% CI, 0.05–0.71]
- Trunk — 0.00 [95% CI, 0–0.94]
The incidence of systemic local anesthetic toxicity showed different risk profiles at different injection sites. In order of decreasing incidence of systemic toxicity events:
Of the 25,336 peripheral nerve blocks in the study, there were only 22 episodes of local anesthetic toxicity. 12 events occurred in the 20,401 PNBs performed with ultrasound guidance and 10 events in the 4,745 blocks performed without ultrasound.
Meta-analysis of 10 RCTs totalling 633 subjects showed that while pain at rest following laparoscopic surgery was reduced by transverse abdominis plane block, early (0-4 h) pain was only moderately reduced (-2.4 cm) and late pain (24 hours) minimally reduced (-1.3 cm). Pain with movement was not significantly different between TAP blocks and controls.