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pearl
1
The use of volatile anaesthetic agents has a negligible impact on climate change, instead being dominated by our ability to reduce carbon dioxide emissions.
Slingo JM Slingo ME. The science of climate change and the effect of anaesthetic gas emissions. Anaesthesia. 2024 Mar 1; 79 (3): 252260252-260.
  Daniel Jolley
pearl
1
Because it takes at least a year for emitted greenhouse gases to be mixed throughout the troposphere, only desflurane (lifetime 14 years) has even the potential to be fully radioactively effective, compared with isoflurane (1.4 years) & sevoflurane (3.5 years).
Slingo JM Slingo ME. The science of climate change and the effect of anaesthetic gas emissions. Anaesthesia. 2024 Mar 1; 79 (3): 252260252-260.
  Daniel Jolley
pearl
1
Second-generation supraglottic airway devices have a role in selected patients undergoing general anaesthesia for cesarean section.
Sanganee U, Jansen K, Lucas N et al. The role of supraglottic airway devices for caesarean section under general anaesthesia. A scoping literature review with a proposed algorithm for the appropriate use of supraglottic airway devices for caesarean sections. Eur J Anaesthesiol. 2024 Sep 1; 41 (9): 668676668-676.
  Daniel Jolley
pearl
1
There is high variation in the duration of action of a single dose of neuromuscular blocking drugs in children.
Vanlinthout LE, Driessen JJ, Stolker RJ et al. Spontaneous recovery from neuromuscular block after a single dose of a muscle relaxant in pediatric patients: A systematic review using a network meta-analytic and meta-regression approach. Paediatr Anaesth. 2024 Aug 1; 34 (8): 720733720-733.
  Daniel Jolley
pearl
1
Care by female anaesthetists is associated with a lower risk of intraoperative complications, particularly among specialist anaesthetists.
von D, Redaelli S, Wachtendorf LJ et al. Association of anaesthesia provider sex with perioperative complications: a two-centre retrospective cohort study. Br J Anaesth. 2024 Sep 1; 133 (3): 628636628-636.
  Daniel Jolley
pearl
1
The agnostic respiratory stimulant ENA-001 blocks carotid body BK-channels, reversing propofol's impairment of the hypoxic ventilatory response.
Jansen SC, van M, Olofsen E et al. Reversal of propofol-induced depression of the hypoxic ventilatory response by BK-channel blocker ENA-001: a randomized controlled trial. Anesthesiology. 2024 Jun 1; 140 (6): 107610871076-1087.
  Daniel Jolley
pearl
1
Intravenous dexamethasone modestly reduces post-caesarean section pain.
Singh NP, MakkarJeetinder KaurJK, Yadav N et al. The analgesic efficacy of intravenous dexamethasone for postcaesarean pain: A systematic review with meta-analysis and trial sequential analysis. Eur J Anaesthesiol. 2022 Jun 1; 39 (6): 498510498-510.
  Daniel Jolley
pearl
1
Permissive intra-operative hypotension (MAP ≤60 mmHg) was not associated with increased mortality, but perplexingly was associated with reduced AF and hospital stay.
D'Amico F, Fominskiy EV, Turi S et al. Intraoperative hypotension and postoperative outcomes: a meta-analysis of randomised trials. Br J Anaesth. 2023 Nov 1; 131 (5): 823831823-831.
  Daniel Jolley
pearl
1
Perioperative benzodiazepine use is associated with decreased risk of intraoperative awareness but no increase in postoperative delirium unless compared with dexmedetomidine.
Wang E, Belley-Côté EP, Young J et al. Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium: a systematic review and meta-analysis of randomised controlled trials and observational studies. Br J Anaesth. 2023 Aug 1; 131 (2): 302313302-313.
  Daniel Jolley
pearl
1
Transdermal & buccal buprenorphine is associated with a small reduction in pain scores in chronic non-cancer pain.
WongStanley Sau ChingSSCFrom the Department of Anaesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.Laboratory Clinical Research Institute for Pain, Department of Anaesthesiology, The University of Hong Kong,, Chan TH, Wang F et al. Analgesic Effect of Buprenorphine for Chronic Noncancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Anesth. Analg. 2023 Jul 1; 137 (1): 597159-71.
  Daniel Jolley