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Removing retracted and suspicious studies completely reverses the WHO 2016 recommendation for high FiO2 to reduce surgical infections. The scourge of academic misconduct continues!
Myles PS, Carlisle JB, Scarr B. Evidence for compromised data integrity in studies of liberal peri-operative inspired oxygen. Anaesthesia. 2019 May 1; 74 (5): 573-584.
  Daniel Jolley
pearl
1
Erythropoietin further reduces red blood cell transfusion in surgical patients, beyond iron therapy alone.
Kei T, Mistry N, Curley G et al. Efficacy and safety of erythropoietin and iron therapy to reduce red blood cell transfusion in surgical patients: a systematic review and meta-analysis. Can J Anaesth. 2019 Jun 1; 66 (6): 716-731.
  Daniel Jolley
pearl
1
MAC-awake of sevoflurane is modestly lower in patients with end-stage renal failure compared with normal controls.
Wu Y, Jin S, Zhang L et al. Minimum Alveolar Concentration-Awake of Sevoflurane Is Decreased in Patients With End-Stage Renal Disease. Anesth. Analg. 2019 Jan 1; 128 (1): 77-82.
  Daniel Jolley
pearl
1
Intravenous dexamethasone at all studied doses did not prolong median nerve block.
Short A, El-Boghdadly K, Clarke H et al. Effect of intravenous dexamethasone on the anaesthetic characteristics of peripheral nerve block: a double-blind, randomised controlled, dose-response volunteer study. Br J Anaesth. 2020 Jan 1; 124 (1): 92-100.
  Daniel Jolley
pearl
1
Perioperative high inspired oxygen concentrations do not reduce surgical site infections – and may possibly increase infection incidence.
Pryor KO, Fahey TJ, Lien CA et al. Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial. JAMA. 2004 Jan 7;291(1):79-87.
  Daniel Jolley
pearl
1
High inspired oxygen concentrations intraoperatively do not reduce surgical site infections, and may potentially have detrimental effects.
Wetterslev J, Meyhoff CS, Jørgensen LN et al. The effects of high perioperative inspiratory oxygen fraction for adult surgical patients. Cochrane Db Syst Rev. 2015 Jun 25; 2015 (6): CD008884CD008884.
  Daniel Jolley
pearl
1
No difference in post-operative atelectasis was observed after non-abdominal surgery for patients having PEEP either maintained or withdrawn before emergence.
Östberg E, Thorisson A, Enlund M et al. Positive End-expiratory Pressure and Postoperative Atelectasis: A Randomized Controlled Trial. Anesthesiology. 2019 Oct 1; 131 (4): 809-817.
  Daniel Jolley
pearl
1
In the context of optimal, individualised lung ventilation, high inspired oxygen does not reduce surgical infections compared with conventional FiO2.
Ferrando C, Aldecoa C, Unzueta C et al. Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial. Br J Anaesth. 2020 Jan 1; 124 (1): 110-120.
  Daniel Jolley
pearl
1
There is no clinically significant difference in the duration of low-dose interscalene block between perineural and intravenous dexamethasone.
McHardy PG, Singer O, Awad IT et al. Comparison of the effects of perineural or intravenous dexamethasone on low volume interscalene brachial plexus block: a randomised equivalence trial. Br J Anaesth. 2020 Jan 1; 124 (1): 84-91.
  Daniel Jolley
pearl
1
Intraoperative PEEP and recruitment manoeuvres reduce ultrasound-detected atelectasis intraoperatively but showed no post-extubation benefit after open gynaecological surgery.
Généreux V, Chassé M, Girard F et al. Effects of positive end-expiratory pressure/recruitment manoeuvres compared with zero end-expiratory pressure on atelectasis during open gynaecological surgery as assessed by ultrasonography: a randomised controlled trial. Br J Anaesth. 2020 Jan 1; 124 (1): 101-109.
  Daniel Jolley