Article Notes

• Hide
  • Pearls
  • Summaries
  • Comments

comment
1
"Xenopus is a genus of highly aquatic frogs native to sub-Saharan Africa. Twenty species are in the Xenopus genus" – interesting animal to use really.
Okura D, Horishita T, Ueno S et al. Lidocaine Preferentially Inhibits the Function of Purinergic P2X7 Receptors Expressed in Xenopus Oocytes. Anesth. Analg. 2015 Mar 1; 120 (3): 597-605.
  pdg.50
pearl
1
BIS monitoring significantly reduces the risk of awareness under general anesthesia in high-risk adult surgical patients.
Myles PS, Leslie K, McNeil J et al. Bispectral index monitoring to prevent awareness during anaesthesia: the B-Aware randomised controlled trial. Lancet. 2004 May 29;363(9423):1757-63.
  Daniel Jolley
comment
1
Caveat - the Cochrane review noted low level evidence for changes in length of hospital stay or reduced complications, 2' to poor blinding in some studies. Safe as fasting though.
Nygren J, Thorell A, Ljungqvist O. Preoperative oral carbohydrate therapy. Curr Opin Anaesthesiol. 2015 Jun 1;28(3):364-9.
  pdg.50
pearl
1
Reversal with sugammadex may reduce post-operative pulmonary complications in the elderly and ASA 3/4 patients.
Ledowski T, Falke L, Johnston F et al. Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: Sugammadex, neostigmine or no reversal. Eur J Anaesthesiol. 2014 Aug 1;31(8):423-9.
  Daniel Jolley
pearl
1
Reversal with sugammadex reduces the incidence of post-operative nausea and vomiting compared with neostigmine.
Ledowski T, Falke L, Johnston F et al. Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: Sugammadex, neostigmine or no reversal. Eur J Anaesthesiol. 2014 Aug 1;31(8):423-9.
  Daniel Jolley
pearl
1
Nebulized ketamine with dexmedetomidine is suitable and effective for pediatric premedication before outpatient dental surgery.
Zanaty OM El SA. A Comparative Evaluation of Nebulized Dexmedetomidine, Nebulized Ketamine, and Their Combination as Premedication for Outpatient Pediatric Dental Surgery. Anesth. Analg. 2015 Jul 1; 121 (1): 167-171.
  Daniel Jolley
pearl
1
Propofol is best dosed by total body weight, and remifentanil by ideal body weight.
Liu N, Lory C, Assenzo V et al. Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison† Br J Anaesth. 2015 Apr 1;114(4):605-14.
  Daniel Jolley
pearl
1
Closed-loop delivery of total intravenous anesthesia with propofol and remifentanil, guided by BIS, is feasible in obese patients.
Liu N, Lory C, Assenzo V et al. Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison† Br J Anaesth. 2015 Apr 1;114(4):605-14.
  Daniel Jolley
pearl
1
Learning in a simulated anesthesia crisis is better when the simulation is of independent practice than supervised practice.
Goldberg A, Silverman E, Samuelson S et al. Learning through simulated independent practice leads to better future performance in a simulated crisis than learning through simulated supervised practice. Br J Anaesth. 2015 May 1;114(5):794-800.
  Daniel Jolley
pearl
1
Intrathecal fentanyl prolongs post-operative analgesia at the expense of increased incidence of pruritus, but with no increase in respiratory depression.
Pöpping DM, Elia N, Marret E et al. Opioids added to local anesthetics for single-shot intrathecal anesthesia in patients undergoing minor surgery: a meta-analysis of randomized trials. Pain. 2012 Apr 1;153(4):784-93.
  Daniel Jolley