• Vera Lucia Chagas, Fernando Colonna Rosman, and Maria da Gloria da Costa Carvalho.
• . Professora no Departamento de Patologias, Faculdade de Medicina do Hospital Clementino Fraga Filho da Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
• Rev Assoc Med Bras (1992). 2020 Jan 1; 66 (1): 87-94.

ObjectivesTo review the literature and the diagnosis of conventional histopathological routine and immunohistochemistry of the cases diagnosed with Solid Pseudopapillary Neoplasm of the Pancreas (SPNP).MethodsThe review of the literature was done using the Pubmed and solid Google-Scholar databases, through the historical, clinical aspects and diagnostic methods of SPNP. The review of SPNP cases diagnosed in the University Hospital Clementino Fraga Filho was carried out from 1977 to 2018.ResultsIntratumoral phenotypic heterogeneity of SPNP was evidenced in the cases studied, taking into account macroscopic, microscopic, and immunohistochemical patterns.ConclusionsThe results show the importance of the examination of several fragments obtained from different regions of the neoplasia since not all of them present the same molecular alterations.

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