• Internal medicine · Feb 2020

    Case Reports

    Pathological and Radiological Correlation in Prolonged Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody-related Diffuse Alveolar Hemosiderosis.

    • Takeshi Saraya, Masachika Fujiwara, Takuma Yokoyama, Saori Takata, Teruaki Oka, Haruyuki Ishii, and Hajime Takizawa.
    • Department of Respiratory Medicine, Kyorin University School of Medicine, Japan.
    • Intern. Med. 2020 Feb 1; 59 (3): 415-419.

    AbstractA 60-year-old woman with a 20-year history of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis visited our hospital due to productive cough and a low-grade fever for several weeks. Thoracic computed tomography demonstrated scattered tiny nodules, patchy consolidation, ground glass opacities, and thickening interlobular septa. On video-assisted thoracic surgery, those abnormalities were found to correspond to the accumulation of hemosiderin-laden alveolar macrophages (AMs) in the alveolar spaces and alveolar septa due to MPO-ANCA vasculitis. The radiological findings persisted for a further two years, indicating the possibility of persistent vasculitis in the lung or evidence of incomplete clearance of hemosiderin-laden AMs.

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