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- C J Fleming, M J Hunt, E L Salisbury, S W McCarthy, and R S Barnetson.
- Department of Dermatology, Royal Prince Alfred Hospital, New South Wales, Australia.
- Br. J. Dermatol. 1996 Apr 1; 134 (4): 784-7.
AbstractA 36-year-old man was treated with dapsone, rifampicin and clofazimine for borderline lepromatous leprosy. After 9 months, his leprosy plaques became progressively more red and after 23 months, the clofazimine was stopped and he was given minocycline instead. Six weeks later, he developed blue-black pigmentation in his leprosy lesions. The histology was consistent with minocycline-induced hyperpigmentation. This is the first report of minocycline-induced pigmentation in leprosy. We suggest it is important to consider this side-effect before the administration of minocycline in leprosy, particularly if it is prescribed in place of clofazimine.
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