• Leandra A Amado, Helen Perrie, Juan Scribante, and Karin-Ann Ben-Israel.
• Department of Anaesthesiology, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: leandra.amado@gmail.com.
• Br J Anaesth. 2020 Sep 1; 125 (3): 275-281.

BackgroundCognitive dysfunction after surgery includes delirium and postoperative cognitive dysfunction. Important risk factors for these include increased age and pre-existing cognitive dysfunction. This study describes preoperative cognitive dysfunction and its associated factors in patients aged ≥60 yr awaiting elective noncardiac surgery in a developing country.MethodsA prospective, contextual, descriptive study design with consecutive convenience sampling was used at Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa. Assessment of cognition was subjective (through casual conversation, henceforth referred to as observer assessment) and objective (using the Mini-Cog test).ResultsA total of 194 outpatients (median age: 65 yr) were assessed. A score ≤3 (indicating mild cognitive impairment) was obtained by 111 patients (57.2%). Subjective memory complaints were reported by 124 patients (63.9%). Univariate analyses demonstrated significant associations between low Mini-Cog scores and increasing age (rs=-0.1901; P=0.0079), unskilled occupation (P=0.0033), low functional status (rs=-0.1831; P=0.0106), low level of education (P=0.0005), and frailty (rs=-0.3010; P<0.0001). Logistic regression showed level of education and frailty to be significant. A score ≤3 is more likely in frail patients (odds ratio: 7.54; P=0.003) and those with only primary school education (odds ratio: 3.54; P=0.003).ConclusionsUndiagnosed pre-existing cognitive dysfunction was common in older patients awaiting surgery at a regional academic hospital in South Africa. Patients at risk for cognitive dysfunction should be identified through brief preoperative screening.Copyright © 2020 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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