• J. Med. Microbiol. · Jun 2005

    Role of Pseudomonas aeruginosa quorum-sensing systems in a mouse model of chronic respiratory infection.

    • Yoshifumi Imamura, Katsunori Yanagihara, Kazunori Tomono, Hideaki Ohno, Yasuhito Higashiyama, Yoshitsugu Miyazaki, Yoichi Hirakata, Yohei Mizuta, Jun-Ichi Kadota, Kazuhiro Tsukamoto, and Shigeru Kohno.
    • Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
    • J. Med. Microbiol. 2005 Jun 1; 54 (Pt 6): 515-518.

    AbstractThe role of quorum-sensing systems in a mouse model of chronic Pseudomonas aeruginosa infection was studied. A chronic P. aeruginosa respiratory infection model was established by placement of a tube pre-coated with strain PAO1 (wild-type) or a quorum-sensing mutant, namely PAO-JP1 (Delta lasI), PDO100 (Delta rhlI) or PAO-JP2 (Delta lasI/Delta rhlI), in the bronchus. At day 14 after infection, the numbers of viable bacteria in the quorum-sensing-mutant groups were lower than in the wild-type group. Histopathological examination showed milder inflammatory changes in the lungs infected with the mutant groups compared with the wild-type group. In the bronchoalveolar lavage fluid from the quorum-sensing-system-mutant groups the proportion of neutrophils was lower than in wild-type group. These findings indicate that the quorum-sensing system plays an important role in chronic P. aeruginosa respiratory infection.

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