• Medicina clinica · Aug 2020

    Review

    Efficacy of ursodeoxycholic acid combined with prednisolone and immunosuppressant triple therapy in the treatment of refractory primary biliary cholangitis.

    • Tian-Tian Yao, Jian-Dan Qian, and Gui-Qiang Wang.
    • Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, P.R., China.
    • Med Clin (Barc). 2020 Aug 28; 155 (4): 165-170.

    Background And AimTo explore the efficacy treatment regimen in refractory PBC.MethodsTriple treatment including ursodeoxycholic acid, prednisolone and immunosuppressant was prescribed to 47 refractory patients. Biochemistries, immune parameters, non-invasive liver fibrosis assessments were measured during follow-up.ResultsTriple therapy resulted in significant decrease in ALP, GGT, ALT, AST, TBIL, ALB, IgG, IgM, APRI, FIB-4 and S-INDEX. The biochemical cumulative normalization rates of ALP and other biochemical parameters were higher in long-term follow-up. Poor outcome was observed in patients with lower ALB, higher TBIL, PT, sp100 positivity and advanced liver pathology at baseline. Osteoporosis and bone fracture were observed in 15% patients.ConclusionsTriple therapy is associated with marked decrease and normalization of ALP and other parameters. ALB, TBIL, PT, sp100 and pathology were related with poor outcome. Osteoporosis should be closely monitored.Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

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