• Zentralbl Gynakol · Sep 2001

    Randomized Controlled Trial Clinical Trial

    [Effect of Urapidil in antihypertensive therapy of preeclampsia on newborns].

    • M Schulz, J Wacker, and G Bastert.
    • Universitäts-Frauenklinik, Heidelberg. michael_schulz@med.uni-heidelberg.de
    • Zentralbl Gynakol. 2001 Sep 1; 123 (9): 529-33.

    ObjectiveFor the therapy of preeclamptic patients is Urapidil besides Dihydralazine another possible option for iv-therapy with good results in first clinical studies. Effects of both drugs on the newborns were observed. -MethodsThe maternal and fetal Urapidil plasma-concentrations and cardiovascular parameters of the newborns were observed in a randomised comparative therapy-study. -ResultsWe found low fetal Urapidil plasma-concentrations as well as a less influence on cardiovascular parameters compared to dihydralazine. -DiscussionWith Urapaidil we have another therapeutic option in preeclampsia where we could not show any negative side-effects on the newborns.

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