• Int. J. Neurosci. · Nov 2012

    Review

    Mechanisms and clinical evidence of the pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in central nervous system disorders: a comprehensive review.

    • Danielle Yanuck, Christos G Mihos, and Orlando Santana.
    • 1Department of Internal Medicine at Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
    • Int. J. Neurosci. 2012 Nov 1; 122 (11): 619-29.

    AbstractThe hydroxy-methyl-glutaryl-CoA reductase inhibitors, better known as statins, are principally used in the treatment of hyperlipidemia and play a pivotal role in the primary and secondary prevention of atherosclerotic heart disease and stroke. Evidence also exists for the potential benefits from statin use in a variety of other disease processes, conferred via their non-lipid lowering properties, which are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropic effects of statins in neurological disorders. Emphasis is placed on the discussion of randomized, placebo-controlled trials, and their importance in further elucidating this interesting phenomenon.

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