• Margrit Fässler, Markus Gnädinger, Thomas Rosemann, and Nikola Biller-Andorno.
• Institute of Biomedical Ethics, University of Zurich, Zurich, Switzerland.
• Br J Gen Pract. 2011 Feb 1; 61 (583): 101-7.

BackgroundFew studies have investigated whether patients and physicians differ in their attitudes regarding placebo interventions in medical practice.AimTo compare the proportions of patients and physicians who would accept therapies that do not work through specific pharmacological or physiological action but by enhancing self-healing capacities and by exploiting contextual factors.Design Of StudySurvey of a random sample of GPs and patients consecutively attending in primary care practices.SettingFour hundred and seventy-seven patients and 300 GPs from primary care practices of the Canton Zurich of Switzerland were approached.MethodTwo questionnaires on responders' attitudes regarding non-specific therapies.ResultsThe response rates were 87% for patients and 79% for GPs. Eighty-seven per cent of patients and 97% of GPs thought that physical complaints can get better by believing in the effectiveness of the therapy. Overall there was more support for placebo interventions among patients than among GPs, yet 90% of the physicians admitted to actively proposing treatments intended to take advantage of non-specific effects. Seventy per cent of the patients wanted to be explicitly informed when receiving a non-specific intervention, whereas physicians thought this was the case for only 33% of their patients. Fifty-four per cent of patients would be disappointed when learning they had unknowingly been treated with pure placebo ('sugar pill'), while only 44% would feel that way after treatment with impure placebo (for example, herbal medicine).ConclusionGPs rather underestimate the openness of their patients to non-specific therapies. However, patients want to be appropriately informed. Developing specific professional standards could help physicians to harness the 'power of the placebo', while remaining authentic and credible.

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