• Yiru Wang, Yifan Zhang, Jing Wei, Wenting Du, Jie Ding, Yiyi Zhang, Na Zhang, Meijiao Mao, and Ping Liu.
• Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 Jul 31; 99 (31): e21407.

BackgroundCoronary artery disease (CAD) is a clinically common coronary heart disease. Vitamin D might be beneficial in CAD patients through its favorable effects on inflammation biomarkers. This study will be performed to examine the effects of Vitamin D supplementation on inflammatory markers in CAD patients.MethodsWe will search the electronical databases and hand-searching journals or reference lists. The study screening and data extraction will be carried out by 2 investigators independently. The primary outcome is inflammatory biomarkers of peripheral blood. Secondary outcomes are triglyceride, total cholesterol, high-density lipoprotein cholesterol levels, low-density lipoprotein cholesterol, and blood pressure. Review Manager (RevMan, version 5.3; The Nordic Cochrane Centre, Copenhagen, Denmark: http://community.cochrane.org) V.5.3 software will be used to compute the data.ResultsThe results of the study will provide a reliable evidence to assess the efficacy of Vitamin D supplement on inflammation biomarkers of CAD patients.ConclusionThe conclusion of our systematic review will answer whether Vitamin D is an effective intervention to relieve inflammation of CAD patients.EthicsBecause all of the data used in this review has been published, this review does not require ethical approval.Registration NumberINPLASY202060072.

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