• Nurdan Bedirli, Erkan Matkap, and Haluk Gümüş.
• Department of Anesthesiology and Reanimation, Diskapi Yildirım Beyazıt Training and Research Hospital, Ankara 06434, Turkey.
• J Clin Anesth. 2011 May 1;23(3):197-201.

Study ObjectiveTo compare the effects of preoperative intravenous (IV) tramadol and preoperative tramadol infiltration of trocar sites on postoperative pain and postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy.DesignProspective, randomized study.SettingOperating room, recovery room, and surgical ward.Patients70 ASA physical status 1 and 2 patients, aged 20-70 years, scheduled for elective laparoscopic cholecystectomy.InterventionsIn Group I, patients received IV 2.0 mg/kg of tramadol; in Group II, trocar insertion points were infiltrated with 2.0 mg/kg of tramadol in 20 mL of 0.9% NaCl.MeasurementsPain scores, sedation scores, postoperative analgesic requirement, and PONV were recorded at 0 and 30 minutes and one, three, 6, 12, and 24 hours. At 30 minutes and one hour, pain localization (incisional or diffuse abdominal) was also recorded.Main ResultsVisual analog scale scores at 30 minutes were significantly lower in Group II [3 (0-7)] than Group I [6 (3-8)] (P < 0.001). In Group I, 91.4% of patients received sodium diclofenac, while 68.6% of Group II patients received sodium diclofenac (P = 0.002). The time to first analgesic requirement was significantly lower in Group II (P = 0.004). At the 30-minute measurement time, a significant difference was recorded between the groups in incisional pain (P < 0.001). There was also a significant difference between groups in the frequency of PONV.ConclusionsTrocar site infiltration of tramadol improves early postoperative pain and decreases PONV.Copyright © 2011 Elsevier Inc. All rights reserved.

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