• Zheng Li, Yitong Cai, Qian Zhang, Peng Zhang, Ruixiang Sun, Haijiao Jiang, JingJing Wan, Fang Wu, Xiaoye Wang, and Xiubin Tao.
• Graduate College, Wannan Medical College, Wuhu.
• Medicine (Baltimore). 2020 Aug 21; 99 (34): e21926e21926.

BackgroundIntensive care unit-acquired weakness (ICU-AW) is an acquired neuromuscular lesion and a common occurrence in patients who are critically ill. There are already systematic reviews on ICU-AW. Therefore, we provide a protocol for an overview of systematic reviews to improve the effectiveness of the construction of an evidence-based practice for prevention of ICU-AW.MethodsWe will search the PubMed, CINAHL, EMBASE, and the Cochrane Library for the relevant systematic review or meta-analyses about ICU-AW. Study selection, data extraction, and the quality assessment of the included studies will be performed independently by 2 reviewers. And the methodological quality, report quality and evidence quality will be evaluated by Assessment of Multiple Systematic Reviews-2 tool, Preferred Reporting Items for Systematic Reviews and Meta Analyses Statement checklist and Grading of Recommendations Assessment, Development and Evaluation system, respectively.ResultsThis overview of systematic reviews and meta-analysis will collect the evidence published about the ICU-AW.ConclusionWe hope that our research will contribute to clinicians and public decision making about the ICU-AW.Registration NumberINPLASY202070067.

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