• Internal medicine · Feb 2020

    Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.

    • Takaaki Higashihara, Akira Okada, Yasuna Nakamura, Hanako Saigusa, Shiko Homma, Mimiko Matsumura, Taiko Kusano, Akira Shimizu, and Hideki Takano.
    • Department of Nephrology, Tokyo Teishin Hospital, Japan.
    • Intern. Med. 2020 Feb 15; 59 (4): 557-562.

    AbstractWe performed a renal biopsy for nephrotic syndrome in a patient with squamous cell lung carcinoma, which can worsen the prognosis. Chemoradiation therapy was effective for the cancer and proteinuria; we thus inferred that the nephrotic syndrome had been closely associated with the carcinoma. A pathological analysis of the kidney showed monoclonality for λ chain, satisfying the diagnostic criteria of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID); however, conspicuous mesangial proliferation was not observed. This is the first case of PGNMID complicated with lung carcinoma; furthermore, our findings underscore the importance of examining renal lesions and assessing monoclonality in cancer patients.

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