• Li Maocai, Liu Fuxing, Li Lianqing, Gong Lili, Duan WenChao, and Liu ShouZhou.
• Department of Otolaryngology, Head and Neck Surgery, Liaocheng People's Hospital, Liaocheng, Shandong, China.
• Medicine (Baltimore). 2020 Aug 14; 99 (33): e21599.

IntroductionThyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and the abnormal expression of thyroid transcription factor-1 (TTF-1). We herein report a rare case of TL-LGNPPA with a review of its clinical and morphological characteristics and the treatment provided.Patient Concerns And DiagnosisThe patient was a 50-year-old Chinese woman with the complaint of a three-year history of phlegm with blood with pharyngeal discomfort. There were no remarkable physical findings, and the laboratory tests were normal. Laryngoscopy and nasal computed tomography identified a mass at the posterior end of the nasal septum. Histologically, the tumor exhibited an oval papillary growth. Immunohistochemically, the neoplastic cells were positive for TTF-1, vimentin, cytokeratin 7, and cytokeratin 19. Pathological examination indicated a thyroid-like low-grade nasopharyngeal papillary adenocarcinoma.InterventionThe neoplasm was completely resected without any complication.OutcomesThe patient had neither local recurrence nor distant metastasis 1 year after the removal of the tumor.ConclusionAlthough TL-LGNPPA is a malignant tumor, complete surgical resection is an effective treatment.

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