• Li-Nan Gao, Lian-Gang Ge, Ming-Zhe Zhu, and Xin-Xin Yao.
• aDepartment of Laboratory, Affiliated Hospital of Jilin Medical University bDepartment of Radiotherapy, The Second People's Hospital of Jilin cDepartment of Obstetrics and Gynecology dDepartment of Pathology, Affiliated Hospital of Jilin Medical University, Jilin, Jilin Province, China.
• Medicine (Baltimore). 2020 Aug 14; 99 (33): e21667.

BackgroundThis study will explore the association between tumor necrosis factor α (TNF-α) and uterine fibroids (UFs).MethodsWe will retrieve electronic databases in Cochrane Library, PUBMED, EMBASE, Web of Science, WANGFANG, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from inception to the present. All potential case-controlled studies investigating the association between TNF-α and UFs will be included in this study. Two researchers will independently select literature, appraise study quality, and extract outcome data. We will utilize a fixed-effects model or a random-effects model to synthesize outcome data. All data analysis will be performed by RevMan 5.3 software.ResultsThe present study will supply high-quality synthesis and/or descriptive analysis of the recent evidence to explore the association between TNF-α and UFs.ConclusionThis study will exert evidence to determine whether or not TNF-α is associated with UFs.Study Registration NumberINPLASY202070010.

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