• Medicine · Aug 2020

    Observational Study

    Relationship between chemotherapy-induced adverse reactions and health-related quality of life in patients with breast cancer.

    • Blanca Prieto-Callejero, Francisco Rivera, Javier Fagundo-Rivera, Adolfo Romero, Macarena Romero-Martín, Juan Gómez-Salgado, and Carlos Ruiz-Frutos.
    • aHospital Virgen de la Bella, Lepe, Huelva bDepartment of Experimental Psychology, Faculty of Psychology, University of Seville, Seville cDepartment of Health and Emergencies, Spanish Red Cross, Local Committee of Seville, Doctoral Programme, University of Huelva, Huelva dUniversity Hospital Virgen de la Victoria, Nursing and Podiatry Department, Health Sciences School, University of Málaga, Málaga eNursing Department, Faculty of Nursing, University of Huelva fPreventive Medicine and Public Health Unit, Sociology, Social Work and Public Health Department, Labour Sciences Faculty, University of Huelva, Huelva, Spain gSafety and Health Postgraduate Programme, Universidad Espíritu Santo, Guayaquil, Ecuador.
    • Medicine (Baltimore). 2020 Aug 14; 99 (33): e21695.

    Background And ObjectivesChemotherapy does not only affect cancer cells; it also affects, to a greater or lesser degree, all other cells in the body. This toxicity should be assessed according to its severity, frequency, and duration, taking into account objective and subjective dimensions in its assessment. This assessment is a highly relevant aspect when providing care to chemotherapy patients, mainly due to the impact of the treatment on the patient's quality of life, as well as the vital risk it may imply under certain circumstances. For all this, the objective of this study was to assess the relationship between chemotherapy-associated adverse reactions and health-related quality of life in breast cancer patients.Materials And MethodsWith this purpose, a descriptive cross-sectional study was developed on 110 breast cancer patients who were treated with docetaxel, epirubicin, and cyclophosphamide.ResultsIt is worth highlighting the negative effect of nausea, dysgeusia, peripheral neuropathy, loss of appetite, myalgia, and peripheral edema on the quality of life. Likewise, it is worth mentioning peripheral neuropathy as the toxicity that affects a greater number of quality-of-life indicators.ConclusionsTo sum up, it would be necessary to make health professionals aware of the importance of chemotherapy-associated adverse reactions.

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