• Sara Darbandi, Mahsa Darbandi, Hamid Reza Khorram Khorshid, Mohammad Reza Sadeghi, Ashok Agarwal, Pallav Sengupta, Safaa Al-Hasani, and Mohammad Mehdi Akhondi.
• Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
• Reprod Biol Endocrin. 2017 Oct 2; 15 (1): 77.

BackgroundOoplasmic transfer (OT) technique or cytoplasmic transfer is an emerging technique with relative success, having a significant status in assisted reproduction. This technique had effectively paved the way to about 30 healthy births worldwide. Though OT has long been invented, proper evaluation of the efficacy and risks associated with this critical technique has not been explored properly until today. This review thereby put emphasis upon the applications, efficacy and adverse effects of OT techniques in human.Main BodyAvailable reports published between January 1982 and August 2017 has been reviewed and the impact of OT on assisted reproduction was evaluated. The results consisted of an update on the efficacy and concerns of OT, the debate on mitochondrial heteroplasmy, apoptosis, and risk of genetic and epigenetic alteration.Short ConclusionThe application of OT technique in humans demands more clarity and further development of this technique may successfully prove its utility as an effective treatment for oocyte incompetence.

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