• Yoshinaga Kajimoto, Toshihiko Kuroiwa, Shin-Ichi Miyatake, Tsugumichi Ichioka, Minoru Miyashita, Hidekazu Tanaka, and Motomu Tsuji.
• Departments of'Neurosurgery, Osaka Medical College, Osaka, Japan. neu039@poh.osaka-med.ac.jp
• J. Neurosurg. 2007 Jun 1; 106 (6): 1070-4.

AbstractIt has been established that fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) is useful in glioma surgery. The authors report on a 65-year-old woman who had a huge atypical left-hemisphere meningioma, which extended into the skull and to the superior sagittal sinus and demonstrated fluorescence in response to administration of 5-ALA. After the tumor was removed, the operative field was observed under the fluorescent mode of a fluorescence surgical microscopy system. Several minute areas of residual tumor tissue were visualized as strong fluorescence behind the vein and sinus, in a part of the hypertrophic dura, and along the edge of the skull. These remnants were completely removed. The authors concluded that fluorescence-guided resection using 5-ALA is useful in cases of atypical meningiomas with a high risk of recurrence.

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