• Internal medicine · Nov 2020

    Case Reports

    Acute Hypertriglyceridaemia Caused by Tocilizumab in a Patient with Severe COVID-19.

    • Hideta Nakamura, Kazuya Miyagi, Mariko Otsuki, Yuuri Higure, Naoya Nishiyama, Takeshi Kinjo, Masashi Nakamatsu, Shusaku Haranaga, Masao Tateyama, and Jiro Fujita.
    • Department of Infectious Disease, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Japan.
    • Intern. Med. 2020 Nov 15; 59 (22): 2945-2949.

    AbstractTreatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release syndrome (CRS) caused by coronavirus disease 2019 (COVID-19). However, the adverse effects of TCZ on patients with COVID-19 remain unclear. We herein report a patient with COVID-19 treated with TCZ who developed acute hypertriglyceridaemia. Despite favipiravir treatment, acute respiratory distress syndrome developed in a 45-year-old patient with COVID-19; thus, TCZ was initiated. The triglyceride levels greatly increased after TCZ administration. Physicians should consider the negative impact of TCZ on the lipid profile in patients with COVID-19, although COVID-19-induced CRS itself may be an aggravating factor.

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