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J. Thromb. Haemost. · Feb 2018
Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions.
- X Yu, J Tan, and S L Diamond.
- 1024 Vagelos Research Laboratory, Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.
- J. Thromb. Haemost. 2018 Feb 1; 16 (2): 316-329.
AbstractEssentials Neutrophil extracellular traps (NETs) are generated during thrombosis and sepsis. The effect of hemodynamics on NETosis during sterile thrombosis was studied using microfluidics. Pressure gradients > 70 mmHg per mm-clot across sterile occlusions drive shear-induced NETosis. High interstitial hemodynamic forces trigger rapid NET release.© 2017 International Society on Thrombosis and Haemostasis.
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