• Internal medicine · Mar 2021

    Case Reports

    A Case of Anti-glomerular Basement Membrane Glomerulonephritis During the First Trimester of Pregnancy.

    • Hirayasu Kai, Joichi Usui, Takashi Tawara, Mayumi Takahashi-Kobayashi, Ryota Ishii, Ryoya Tsunoda, Akiko Fujita, Kei Nagai, Shuzo Kaneko, Naoki Morito, Chie Saito, Hiromi Hamada, and Kunihiro Yamagata.
    • Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan.
    • Intern. Med. 2021 Mar 1; 60 (5): 765770765-770.

    AbstractA 28-year-old woman was admitted during the eighth week of her pregnancy because her clinical course was consistent with rapid progressive glomerulonephritis (RPGN). Anti-glomerular basement membrane antibody (anti-GBM Ab) and myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) were positive, and the anti-GBM Ab titer being extremely high. She was treated with hemodialysis, plasma exchange and prednisolone. She survived the illness; however, neither the fetus nor her kidney function could be rescued. She had human leukocyte antigen (HLA)-DRB1*1502:01, which differs from the DRB1*1501 associated with anti-GBM GN. When patients have particular symptoms, we should check the urine and serum creatinine to exclude RPGN, even in cases of pregnancy.

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