• Roie Etinger, Doron Comaneshter, Howard Amital, Arnon D Cohen, and Shmuel Tiosano.
• Faculty of Medicine, Tel Aviv University Sackler, Tel Aviv, Israel.
• Postgrad Med. 2021 Mar 1; 133 (2): 202-208.

ObjectiveTo evaluate the proportion and the long-term prognostic significance of heart failure (HF) in sarcoidosis patients.MethodsData extracted from a large Israeli healthcare provider's database were used to study sarcoidosis patients and matched non-sarcoidosis controls since 2000 to 2016. The proportion of HF was compared between the groups, and the associations between sarcoidosis, HF, and all-cause mortality were assessed.ResultsIncluded were 3,993 sarcoidosis patients and 19,856 age- and sex-matched controls. The proportion of HF patients was higher among the former (10.9% and 5.3%, respectively). A logistic regression model for multivariable analysis for covariates found sarcoidosis to be independently associated with HF (Odds Ratio (OR) 2.09 confidence interval (CI) 1.83-2.39). A total of 710 sarcoidosis patients (17.8%) and 2,121 controls (10.7%) died during the study period (p < 0.001). A multivariable survival analysis found an estimated hazard ratio (HR) of 1.84 (95%CI 1.67-2.02), indicating a significant association between sarcoidosis and risk for all-cause mortality. Our analysis also revealed a significant association between HF and risk for all-cause mortality (HR 3.05, 95%CI 2.77-3.36).ConclusionsSarcoidosis is independently associated with HF, and both are independently associated with all-cause mortality.

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