• César Muñoz-Fontela, William E Dowling, Simon G P Funnell, Pierre-S Gsell, A Ximena Riveros-Balta, Randy A Albrecht, Hanne Andersen, Ralph S Baric, Miles W Carroll, Marco Cavaleri, Chuan Qin, Ian Crozier, Kai Dallmeier, Leon de Waal, Emmie de Wit, Leen Delang, Erik Dohm, W Paul Duprex, Darryl Falzarano, Courtney L Finch, Matthew B Frieman, Barney S Graham, Lisa E Gralinski, Kate Guilfoyle, Bart L Haagmans, Geraldine A Hamilton, Amy L Hartman, Sander Herfst, Suzanne J F Kaptein, William B Klimstra, Ivana Knezevic, Philip R Krause, Jens H Kuhn, Roger Le Grand, Mark G Lewis, Wen-Chun Liu, Pauline Maisonnasse, Anita K McElroy, Vincent Munster, Nadia Oreshkova, Angela L Rasmussen, Joana Rocha-Pereira, Barry Rockx, Estefanía Rodríguez, Thomas F Rogers, Francisco J Salguero, Michael Schotsaert, Koert J Stittelaar, Thibaut Hendrik Jan HJ http://orcid.org/0000-0001-5785-8276 KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Labo, Chien-Te Tseng, Júlia Vergara-Alert, Martin Beer, Trevor Brasel, Chan Jasper F W JFW Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Adolfo García-Sastre, Johan Neyts, Stanley Perlman, Douglas S Reed, Juergen A Richt, Chad J Roy, Joaquim Segalés, Seshadri S Vasan, Ana María Henao-Restrepo, and Dan H Barouch.
• Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
• Nature. 2020 Oct 1; 586 (7830): 509-515.

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

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