• Krista A Knudson, Carolina M Gustafson, Lois S Sadler, Robin Whittemore, Nancy S Redeker, Laura K Andrews, Abeel Mangi, and Marjorie Funk.
• Yale School of Nursing, 400 West Campus Drive, Orange, CT 06477, United States. Electronic address: krista.knudson@yale.edu.
• Heart Lung. 2019 Nov 1; 48 (6): 538-552.

BackgroundExtracorporeal membrane oxygenation (ECMO), a rescue treatment for patients with severe pulmonary and/or cardiac dysfunction, is increasingly being used worldwide. A better understanding of long-term health-related quality of life (HRQOL) is needed.ObjectiveTo synthesize research on long-term (at least 6 months post-ECMO) HRQOL of adults treated with ECMO.MethodsIn this integrative review, we searched 3 electronic databases and did a hand search of relevant journals for articles published 2000-2019, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.ResultsThirty-one studies, representing 913 patients treated with ECMO, were included. Long-term HRQOL was slightly better for patients treated with veno-venous ECMO than veno-arterial ECMO, and mental health outcomes tended to be better than physical ones. Survivors frequently experienced physical complications, functional limitations, anxiety, depression, and post-traumatic stress symptoms, although improvements were observed over time.ConclusionsEarly identification and management of physical and mental health problems may improve HRQOL outcomes.Copyright © 2019 Elsevier Inc. All rights reserved.

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