• Current biology : CB · Aug 2001

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    Wnt signalling: antagonistic Dickkopfs.

    • A M Zorn.
    • Wellcome/CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK.
    • Curr. Biol. 2001 Aug 7; 11 (15): R592-5.

    AbstractDickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt--Frizzled--LRP5/6 receptor complexes, thus blocking the canonical Wnt--beta-catenin pathway.

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