• Joseph A Mellia, Marten N Basta, Yoshiko Toyoda, Sammy Othman, Omar Elfanagely, Martin P Morris, Luke Torre-Healy, Lyle H Ungar, and John P Fischer.
• Division of Plastic Surgery, Department of Surgery, University of Pennsylvania. Philadelphia, PA.
• Ann. Surg. 2021 May 1; 273 (5): 900-908.

ObjectiveThe aim of this study was to systematically assess the application and potential benefits of natural language processing (NLP) in surgical outcomes research.Summary Background DataWidespread implementation of electronic health records (EHRs) has generated a massive patient data source. Traditional methods of data capture, such as billing codes and/or manual review of free-text narratives in EHRs, are highly labor-intensive, costly, subjective, and potentially prone to bias.MethodsA literature search of PubMed, MEDLINE, Web of Science, and Embase identified all articles published starting in 2000 that used NLP models to assess perioperative surgical outcomes. Evaluation metrics of NLP systems were assessed by means of pooled analysis and meta-analysis. Qualitative synthesis was carried out to assess the results and risk of bias on outcomes.ResultsThe present study included 29 articles, with over half (n = 15) published after 2018. The most common outcome identified using NLP was postoperative complications (n = 14). Compared to traditional non-NLP models, NLP models identified postoperative complications with higher sensitivity [0.92 (0.87-0.95) vs 0.58 (0.33-0.79), P < 0.001]. The specificities were comparable at 0.99 (0.96-1.00) and 0.98 (0.95-0.99), respectively. Using summary of likelihood ratio matrices, traditional non-NLP models have clinical utility for confirming documentation of outcomes/diagnoses, whereas NLP models may be reliably utilized for both confirming and ruling out documentation of outcomes/diagnoses.ConclusionsNLP usage to extract a range of surgical outcomes, particularly postoperative complications, is accelerating across disciplines and areas of clinical outcomes research. NLP and traditional non-NLP approaches demonstrate similar performance measures, but NLP is superior in ruling out documentation of surgical outcomes.Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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