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- Masato Miyake, Kan Katayama, Takashi Ehara, Yoshikazu Sado, Shunpei Nawa, Tomohiro Murata, Yasuhide Mizutani, Kensuke Joh, Masaaki Ito, and Kaoru Dohi.
- Department of Nephrology, Yokkaichi Hazu Medical Center, Japan.
- Intern. Med. 2021 Mar 15; 60 (6): 911-915.
AbstractCollagenofibrotic glomerulopathy or LMX1B-associated nephropathy is a rare disease in which type III collagen accumulates in the glomeruli. We herein report a 64-year-old Japanese woman with an elevated serum creatinine level and persistent proteinuria for 7 years. An electron microscopic study using tannic acid showed curved and frayed collagen fibers within mesangial and subendothelial regions compatible with type III collagen depositions. The distribution of type IV collagen α1-6 chains was normal. Since no pathogenic mutations were identified in the LMX1B gene, she was diagnosed with collagenofibrotic glomerulopathy and treated with angiotensin II receptor blocker and calcium antagonist to control her blood pressure.
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