• J Clin Anesth · Aug 2012

    Case Reports

    Sodium-reduced continuous venovenous hemodiafiltration (CVVHDF) for the prevention of central pontine myelinolysis (CPM) in hyponatremic patients scheduled for orthotopic liver transplantation.

    • Marcus R Lenk and Michael Kaspar.
    • Klinik für Anästhesiologie, Klinikum der Universität München, Campus Grosshadern, Marchioninistrasse 15, D-81377 München, Germany. marcus.lenk@med.uni-muenchen.de
    • J Clin Anesth. 2012 Aug 1;24(5):407-11.

    AbstractTwo patients in end-stage hepatic failure presented for orthotopic liver transplantation with longstanding severe hyponatremia (121 and 122 mmol/L). Both patients underwent liver transplantation with the concomitant use of continuous venovenous hemodiafiltration. Replacement and dialysate solutions were prepared individually to contain a sodium level that was individually considered safe with regard to the development of central pontine myelinolysis. The sodium increase in both patients was within the expected and planned limits despite a situation of mass transfusion. Both patients did well postoperatively and neither patient suffered neurological deficits.Copyright © 2012 Elsevier Inc. All rights reserved.

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