• Best Pract Res Clin Obstet Gynaecol · Jul 2018

    Review

    Noninvasive diagnosis of endometriosis: Review of current peripheral blood and endometrial biomarkers.

    • Dorien F O, Idhaliz Flores, Etienne Waelkens, and Thomas D'Hooghe.
    • KU Leuven, Department of Development and Regeneration, Organ Systems, Leuven, Belgium; Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium.
    • Best Pract Res Clin Obstet Gynaecol. 2018 Jul 1; 50: 72-83.

    AbstractA noninvasive biomarker-based test could help shorten the diagnostic delay for endometriosis. The most investigated biomarker sources are peripheral blood and endometrium. Discovery of endometriosis biomarkers is often hypothesis-driven, i.e. when one or a few biomarkers are investigated based on their role in the disease pathogenesis. Alternatively, a hypothesis-generating approach has been followed using the "omics" technologies. A variety of biomarkers for endometriosis have been investigated, but no biomarker has been validated for clinical use. Many challenges lie ahead in the endometriosis biomarker field. In the future, harmonized collection and reporting methods should allow large-scale international collaboration for highly powered studies.Copyright © 2018. Published by Elsevier Ltd.

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