• Transplantation · Jul 2000

    Case Reports

    Reversible acute renal allograft dysfunction due to gabapentin.

    • B J Gallay, A M de Mattos, and D J Norman.
    • Division of Transplant Medicine, Oregon Health Sciences University, Portland 97201, USA.
    • Transplantation. 2000 Jul 15; 70 (1): 208-9.

    BackgroundThe use of gabapentin as an effective analgesic agent for neuropathic pain has expanded considerably. Its lack of both anticholinergic side effects and interference with the metabolism of drugs via the cytochrome P450 pathway make it especially useful for transplant recipients.Methods And ResultsWe describe the case of a renal transplant recipient with a long-term stable functioning allograft who developed reversible acute renal dysfunction after beginning gabapentin therapy for chronic pain due to diabetic neuropathy.ConclusionsWe suggest that gabapentin may cause acute renal dysfunction by a mechanism involving renal afferent vasoconstriction. Caution should be employed when considering the use of gabapentin in transplant recipients, especially when combined with other agents that may potentiate renal vasoconstriction.

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