• J. Thromb. Haemost. · Oct 2017

    Randomized Controlled Trial Comparative Study

    Dissociation between the pharmacokinetics and pharmacodynamics of once-daily rivaroxaban and twice-daily apixaban: a randomized crossover study.

    • R Kreutz, P B Persson, D Kubitza, K Thelen, S Heitmeier, S Schwers, M Becka, and M Hemmrich.
    • Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
    • J. Thromb. Haemost. 2017 Oct 1; 15 (10): 2017-2028.

    AbstractEssentials In this crossover study the anticoagulant effects of rivaroxaban and apixaban were compared. Healthy volunteers received rivaroxaban 20 mg once daily or apixaban 5 mg twice daily. Rivaroxaban was associated with more prolonged inhibition of thrombin generation than apixaban. Rivaroxaban induced a clear prolongation of prothrombin time and activated partial thromboplastin time.© 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

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