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J. Thromb. Haemost. · May 2018
Multicenter Study Observational StudyLow drug levels and thrombotic complications in high-risk atrial fibrillation patients treated with direct oral anticoagulants.
- S Testa, O Paoletti, C Legnani, C Dellanoce, E Antonucci, B Cosmi, V Pengo, D Poli, R Morandini, R Testa, A Tripodi, and G Palareti.
- Hemostasis and Thrombosis Center, Ospedale di Cremona, Cremona, Italy.
- J. Thromb. Haemost. 2018 May 1; 16 (5): 842-848.
AbstractEssentials Direct oral anticoagulants (DOACs) do not require laboratory monitoring currently. DOAC specific measurements were performed at trough in patients with atrial fibrillation. Patients who developed thromboembolic events showed lower DOAC plasma levels. This study supports the concept of measuring DOAC levels at steady state.© 2018 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.
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