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Journal of neurosurgery · Jun 2003
Randomized Controlled Trial Clinical TrialEffect of the local anesthetic agent bupivacaine prior to application of the skull-pin holder for craniotomies.
- David Mathieu, Mathieu Beaudry, René Martin, Hans McLelland, Bruno Robert, and Brendan Kenny.
- Department of Neurosurgery, Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
- J. Neurosurg. 2003 Jun 1; 98 (6): 1194-7.
ObjectThe authors conducted a double-blind prospective randomized study to determine whether infiltration of Mayfield skull-pin sites with 0.5% bupivacaine, compared with placebo, would prevent hemodynamic stimulation, thus allowing for a reduction in the quantity of anesthetic agents required.MethodsThirty patients were randomized into two groups. There was a significant increase in blood pressure (mean systolic blood pressure 10 mm Hg, p = 0.003) in patients in the placebo group compared with that in patients in the bupivacaine group 1 minute after securing the head holder.ConclusionsThe local administration of bupivacaine for anesthetic purposes before skull-pin application may prevent potentially hazardous hemodynamic stimulation.
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